Proper nutrition plays a crucial role in supporting the optimal functioning of our bodies, and this extends to the intricate world of stem cells. Stem cells are unique cells with the remarkable ability to develop into various specialized cell types in our bodies. They are involved in tissue repair, regeneration, and overall health maintenance. While stem cells have their own innate regenerative capabilities, providing them with the right nourishment can enhance their function and potential. Through a well-balanced diet rich in essential nutrients, vitamins, minerals, antioxidants, and specific supplements we can support and optimize the performance of our stem cells, unlocking their full potential in promoting health and vitality.
Following an anti-inflammatory diet has been suggested to have potential benefits for stem cell function. Chronic inflammation can negatively impact stem cell activity and impair tissue regeneration. An anti-inflammatory diet focuses on consuming whole, nutrient-dense foods that have been found to possess anti-inflammatory properties, such as fruits, vegetables, whole grains, healthy fats, and lean proteins. These foods are rich in antioxidants, vitamins, and minerals that help reduce inflammation and oxidative stress, creating a favorable environment for stem cell activity and function. Additionally, an anti-inflammatory diet promotes a healthy balance of gut microbiota, which plays a crucial role in regulating immune response and inflammation, both of which can influence stem cell behavior. By reducing inflammation, supporting immune function, and providing essential nutrients, an anti-inflammatory diet may contribute to maintaining optimal stem cell function and promoting tissue repair and regeneration.
NeuroGen, a powerful supplement designed by a surgeon with a background in anti-aging medicine, has shown promising effects in promoting an anti-inflammatory condition that can greatly benefit stem cell treatments. Inflammation is a common factor that hinders the optimal functioning of stem cells and their regenerative abilities. NeuroGen contains a unique blend of natural ingredients known for their anti-inflammatory properties, such as turmeric, Acetyl l-carnitine, alpha lipoic acid, methylcobalamin, N Acetylcysteine, COQ 10, Bromelain, and serrapeptase. These ingredients work synergistically to combat inflammation in the body and create an environment that is favorable for stem cell therapy. By reducing inflammation, NeuroGen helps support the survival, migration, and differentiation of stem cells, allowing them to effectively target damaged tissues and promote healing. With its potent anti-inflammatory effects, NeuroGen serves as an excellent complement to stem cell treatment, enhancing its efficacy and optimizing the potential for tissue repair and regeneration.
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Acetyl L-carnitine, popularly known as ALCAR, has been found to have several benefits in promoting stem cell function. Stem cells are the building blocks of our body, with the potential to differentiate into different cell types and aid in tissue repair and regeneration. ALCAR enhances stem cell function by providing crucial support to their energy metabolism.1 It acts as a transport molecule, shuttling fatty acids into the mitochondria, the powerhouse of the cell, where they are converted into usable energy. This improved energy production allows stem cells to proliferate and differentiate more efficiently, facilitating their regenerative potential.2 Additionally, ALCAR also exhibits antioxidant properties, protecting stem cells from oxidative stress and damage, thus preserving their functionality. These combined effects of ALCAR on stem cell metabolism and protection make it a valuable supplement for boosting stem cell function and promoting tissue repair and regeneration.
Alpha lipoic acid has been found to promote the development of hematopoietic progenitors derived from human embryonic stem cells.3 It achieves this by antagonizing signals of reactive oxygen species (ROS), which can inhibit cell apoptosis and autophagy, thus favoring the maintenance and expansion of hematopoietic stem cells.3 Additionally, alpha lipoic acid possesses antioxidant properties, making it an effective "universal antioxidant" that can neutralize free radicals and protect cells from oxidative stress. These benefits of alpha lipoic acid contribute to the enhancement of stem cell function and support their overall health and viability.4
Methylcobalamin, a form of vitamin B12, plays a crucial role in supporting stem cell function. It aids in the production of red blood cells and DNA synthesis, both of which are essential for the growth and maintenance of stem cells.5 Methylcobalamin also helps regulate homocysteine levels, a compound that can impair stem cell function if it accumulates excessively.6 Additionally, this vitamin B12 derivative has been shown to possess neuroprotective effects on neural stem cells, promoting their survival and differentiation into mature neurons. By providing essential nutrients and promoting cellular integrity, methylcobalamin positively impacts stem cell function and contributes to its proper development and functionality.
N-acetylcysteine (NAC) is known to have beneficial effects on stem cell function. It acts as a precursor to glutathione, a potent antioxidant that protects cells from oxidative stress and maintains their integrity. By increasing glutathione levels, NAC helps to neutralize harmful free radicals and reduce cellular damage, which can otherwise hinder stem cell function. Furthermore, NAC possesses anti-inflammatory properties, which can promote a favorable environment for stem cell proliferation and differentiation.7 Studies have also indicated that NAC can protect stem cells from oxidative stress-induced apoptosis, ensuring their survival and allowing them to carry out their regenerative abilities more efficiently.8 Overall, N-acetylcysteine has demonstrated its ability to support stem cell function by providing antioxidant protection, reducing inflammation, and enhancing their viability.
Coenzyme Q10, also known as CoQ10, has been shown to offer numerous benefits for stem cell function. CoQ10 plays a crucial role in energy production within cells, including stem cells, by aiding in the production of adenosine triphosphate (ATP). ATP is essential for maintaining stem cell homeostasis, enabling them to divide and differentiate efficiently. Additionally, CoQ10 is a potent antioxidant that can neutralize free radicals, protecting stem cells against oxidative stress. CoQ10 can also stimulate the expression of genes responsible for cell repair and proliferation. Furthermore, CoQ10 may have anti-inflammatory properties, promoting an optimal environment for stem cell growth and differentiation.9 All of these effects contribute to the enhancement of stem cell function and support their regenerative abilities, making CoQ10 an essential nutrient for promoting tissue repair and maintenance.
Bromelain, a mixture of enzymes derived from pineapples, has been shown to have potential benefits for stem cell function. It has anti-inflammatory properties and can help reduce inflammation, which can hinder stem cell activity and regenerative processes.10 Bromelain also possesses immunomodulatory effects, regulating the immune response and creating a favorable environment for stem cell growth and differentiation. Additionally, studies have suggested that bromelain may enhance the mobilization and homing of stem cells to sites of injury or tissue damage, promoting tissue repair and regeneration. Moreover, bromelain has been shown to possess antioxidant properties, protecting stem cells from oxidative stress and maintaining their viability and functionality. These various mechanisms contribute to the potential benefits of bromelain in supporting stem cell function and promoting tissue healing.
Serrapeptase, also known as serratiopeptidase, is a proteolytic enzyme that has been shown to have potential benefits for stem cell function. It has anti-inflammatory properties and can help reduce inflammation, which can impede stem cell activity and regenerative processes. Serrapeptase can break down harmful proteins, such as fibrin, which can create a hostile environment for stem cells.11 This protease enzyme can also help enhance circulation and the delivery of nutrients to stem cells, promoting their growth and development. Additionally, serrapeptase can help protect stem cells against oxidative stress and reduce cell damage, supporting their viability and function. Furthermore, studies have suggested that serrapeptase may help reduce the risk of cell apoptosis, ensuring the survival of stem cells and maximizing their regenerative potential. Overall, serrapeptase has demonstrated its potential as a valuable nutrient for maintaining stem cell health and promoting tissue repair and regeneration.
Benfotiamine, a form of vitamin B1, has been suggested to have potential benefits for stem cell function. It acts as a potent antioxidant, protecting stem cells from oxidative stress and reducing cellular damage. By neutralizing harmful free radicals, benfotiamine helps maintain the integrity and viability of stem cells, enabling them to carry out their regenerative functions effectively. Additionally, benfotiamine has been shown to possess anti-inflammatory properties, creating a favorable environment for stem cell proliferation and differentiation. It may also help regulate glucose metabolism and promote energy production within stem cells, supporting their growth and functionality. These various mechanisms contribute to the potential benefits of benfotiamine for enhancing stem cell function and promoting tissue repair and regeneration.
Curcumin, a natural compound found in turmeric, has been shown to have potential benefits for stem cell function. It acts as an antioxidant, protecting stem cells against oxidative stress and reducing cellular damage. By neutralizing free radicals, curcumin helps maintain the functionality and viability of stem cells, enabling them to carry out their regenerative functions effectively.12 Additionally, curcumin has been shown to have anti-inflammatory properties, creating a favorable environment for stem cell proliferation and differentiation. Studies have also suggested that curcumin may enhance the migration and homing of stem cells to sites of injury or tissue damage, promoting tissue repair and regeneration. Moreover, curcumin may modulate various signaling pathways involved in stem cell differentiation, promoting the development of specific cell lineages.13 Overall, curcumin has demonstrated its potential as a valuable nutrient for supporting stem cell function and promoting tissue healing.
Krill oil, rich in omega-3 fatty acids, has been suggested to have potential benefits for stem cell function. omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to possess anti-inflammatory properties, which create a conducive environment for stem cell activity and regenerative processes.14 These fatty acids can help reduce inflammation, which can hinder stem cell function and impede tissue repair. Moreover, omega-3 fatty acids have been shown to support cardiovascular health and improve blood circulation, which may enhance the delivery of nutrients and oxygen to stem cells, promoting their growth and functionality. Additionally, these essential fatty acids have neuroprotective effects, potentially influencing the behavior and survival of neural stem cells.15 The incorporation of omega-3 fatty acids from krill oil into the diet may, therefore, offer potential benefits for supporting stem cell function, tissue healing, and overall health.
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Probiotics have been shown to have potential benefits for stem cell function through their modulatory effects on the immune system and gut microbiota.16 The gut microbiota plays a crucial role in regulating immune response and inflammation, which are important factors for the proper functioning of stem cells.17 Probiotic bacteria interact with immune cells and epithelial cells, producing molecules that have immunomodulatory and anti-inflammatory functions. These interactions can create a favorable environment for stem cell activity and support their regenerative functions. Additionally, probiotics have been found to influence the composition of the gut microbiota, which can indirectly impact stem cell function through the modulation of immune and inflammatory responses.18 While more research is needed to fully understand the mechanisms, incorporating probiotics into the diet may have potential benefits for supporting stem cell function and overall health.
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Dr Fitzmaurice is a hand and peripheral nerve surgeon and anti-aging specialist as well as fellowship trained stem cell physician. He has written about the benefits of nutritional intervention to alleviate symptoms from a variety of conditions.
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1. Pan T, Qian Y, Li T, et al. Acetyl l-carnitine protects adipose-derived stem cells against serum-starvation: regulation on the network composed of reactive oxygen species, autophagy, apoptosis and senescence. Cytotechnology. 2022;74(1):105-121. doi:10.1007/s10616-021-00514-y https://pubmed.ncbi.nlm.nih.gov/35185289/
2. Abdolmaleki A, Ghayour MB, Behnam-Rassouli M. Protective effects of acetyl-l-carnitine against serum and glucose deprivation-induced apoptosis in rat adipose-derived mesenchymal stem cells. Cell Tissue Bank. Published online 2020:1-12. doi:10.1007/s10561-020-09844-1 https://pubmed.ncbi.nlm.nih.gov/32564258/
3. Dong Y, Bai J, Zhang Y, et al. Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. J Leukoc Biol. 2020;108(6):1711-1725. doi:10.1002/jlb.1a0520-179r https://pubmed.ncbi.nlm.nih.gov/32640500/
4. Zhang P, Edgar BA. Lipoic acid and autophagy: new insights into stem cell aging. Embo Rep. Published online 2020:e202051175. doi:10.15252/embr.202051175 https://pubmed.ncbi.nlm.nih.gov/32715610/
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https://pubmed.ncbi.nlm.nih.gov/27916629/
7. Hamid ZA, Tan HY, Chow PW, Harto KAW, Chan CY, Mohamed J. The Role of N-Acetylcysteine Supplementation on the Oxidative Stress Levels, Genotoxicity and Lineage Commitment Potential of Ex Vivo Murine Haematopoietic Stem/Progenitor Cells. Sultan Qaboos Univ Méd J. 2017;18(2):e130-e136. doi:10.18295/squmj.2018.18.02.002 https://pubmed.ncbi.nlm.nih.gov/30210840/
8. Zhu Q, Hao H, Xu H, et al. Combination of Antioxidant Enzyme Overexpression and N‐Acetylcysteine Treatment Enhances the Survival of Bone Marrow Mesenchymal Stromal Cells in Ischemic Limb in Mice With Type 2 Diabetes. J Am Heart Assoc. Published online 2021. doi:10.1161/jaha.121.023491 https://pubmed.ncbi.nlm.nih.gov/34569277/
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10. Ghensi P, Cucchi A, Bonaccorso A, et al. In Vitro Effect of Bromelain on the Regenerative Properties of Mesenchymal Stem Cells. J Craniofac Surg. 2018;Publish Ahead of Print(NA;):NA; doi:10.1097/scs.0000000000004862 https://pubmed.ncbi.nlm.nih.gov/30358745/
11. Tiwari M. The role of serratiopeptidase in the resolution of inflammation. Asian J Pharm Sci. 2017;12(3):209-215. doi:10.1016/j.ajps.2017.01.003 https://pubmed.ncbi.nlm.nih.gov/32104332/
12. Wang N, Wang F, Gao Y, et al. Curcumin protects human adipose-derived mesenchymal stem cells against oxidative stress-induced inhibition of osteogenesis. J Pharmacol Sci. 2016;132(3):192-200. doi:10.1016/j.jphs.2016.10.005 https://pubmed.ncbi.nlm.nih.gov/27840063/
13. Zhang R, Zhang Q, Zou Z, et al. Curcumin Supplementation Enhances Bone Marrow Mesenchymal Stem Cells to Promote the Anabolism of Articular Chondrocytes and Cartilage Repair. Cell Transplant. 2021;30:963689721993776. doi:10.1177/0963689721993776 https://pubmed.ncbi.nlm.nih.gov/33588606/
14. Kang JX, Wan JB, He C. Concise review: Regulation of stem cell proliferation and differentiation by essential fatty acids and their metabolites. Stem Cells. 2014;32(5):1092-1098. doi:10.1002/stem.1620 https://pubmed.ncbi.nlm.nih.gov/24356924/
15. Katakura M, Hashimoto M, Okui T, Shahdat HM, Matsuzaki K, Shido O. Omega-3 Polyunsaturated Fatty Acids Enhance Neuronal Differentiation in Cultured Rat Neural Stem Cells. Stem Cells International. 2013;2013(6):1-9. doi:10.1155/2013/490476 https://pubmed.ncbi.nlm.nih.gov/23365582/
16. Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Adv Nutr. 2019;10(suppl_1):S49-S66. doi:10.1093/advances/nmy063 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363529/
17. Mazziotta C, Tognon M, Martini F, Torreggiani E, Rotondo JC. Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health. Cells. 2023;12(1):184. doi:10.3390/cells12010184 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9818925/#:~:text=Probiotic%20bacteria%20can%20interact%20and,health%2Dpromoting%20and%20immunomodulatory%20properties.
18. Wu D, Fu R, Scoffield J, Kannappan R. Probiotic Metabolites Promote Stem Cell Proliferation and Differentiation. Faseb J. 2018;32:615.4-615.4. doi:10.1096/fasebj.2018.32.1_supplement.615.4 https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2018.32.1_supplement.615.4
